大炮明理
发表于 2024-7-9 08:51:08
老年痴呆“特效药”，已进入义乌？
<!----><style type="text/css">html{font-size:375%}</style><link href="https://pics.app.cnyw.net/static/publish/css/style.css?v=1605251010513" rel="stylesheet" position="1" data-qf-origin="/static/publish/css/style.css?v=1605251010513"><!-- 付费贴--> <div class="preview_article "> <!----> <p class="empty_paragraph" style="margin-bottom: 0px; text-wrap: wrap; outline: 0px; font-family: system-ui, -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif; letter-spacing: 0.544px; background-color: #ffffff; text-align: center; visibility: visible;"> </p><p class="empty_paragraph" style="margin-bottom: 0px; text-wrap: wrap; outline: 0px; font-family: system-ui, -apple-system, BlinkMacSystemFont, Helvetica Neue, PingFang SC, Hiragino Sans GB, Microsoft YaHei UI, Microsoft YaHei, Arial, sans-serif; letter-spacing: 0.544px; background-color: #ffffff; text-align: center; visibility: visible;"> </p><p style="margin-bottom: 0px; outline: 0px; font-family: system-ui, -apple-system, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif; letter-spacing: 0.544px; background-color: #ffffff; visibility: visible;"><img class="rich_pages wxw-img" style="vertical-align: baseline; outline: 0px; color: #000000; font-size: 16px; letter-spacing: 0.54px; text-align: left; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; width: 676.969px !important; visibility: visible !important; display: block; margin-left: auto; margin-right: auto;" title="金属质感分割线" src="https://pics.app.cnyw.net/Fp_h4100VyxoZitkSWWx91oQ-HDO" width="640" /></p><section><section><section><section><section><p> </p><p style="text-indent: 2em;"> </p><p><span style="font-size: 16px;">7月4日，市中心医院引进了一位“新成员”——仑卡奈单抗，</span><span style="color: #c00000;"><strong><span style="color: #c00000; font-size: 16px; caret-color: #ff0000; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;">这是阿尔茨海默病靶向治疗新药</span></strong></span><span style="font-size: 16px;">，有需要的患者在“家门口”就可用上国际最前沿的新药剂。</span></p><p style="text-indent: 2em;"> </p><section><section style="margin: 10px auto; display: flex; justify-content: center;"><section style="display: flex; flex-direction: column;"><section style="display: flex; justify-content: flex-start; z-index: 4;"><section style="display: flex; align-items: center; margin-bottom: -25px;"><section style="width: 40px;"></section><section style="width: 40px; text-align: center; margin-left: -40px; z-index: 4;"><section style="font-size: 16px; letter-spacing: 1.5px; color: #ffffff;"><strong>0</strong><strong title="">1</strong></section></section></section></section><section style="margin-left: 15px; display: flex; align-items: flex-end;"><section style="padding: 6px 10px 6px 35px; background-color: #98cc6a; transform: skew(-10deg);"><section style="transform: skew(10deg); -webkit-transform: skew(10deg); -moz-transform: skew(10deg); -o-transform: skew(10deg);"><section style="font-size: 16px; color: #ffffff; text-align: center;"><strong>新药已获国家药监局批准</strong></section></section></section><section style="flex-shrink: 0; margin-left: -6px;"><section style="width: 0px; height: 1px; border-left: 10px solid #81bc4c; border-top: 30px solid transparent; overflow: hidden;"></section></section></section></section></section></section><p style="text-indent: 2em;"> </p><section><section style="margin: 10px auto;"><section style="display: flex; justify-content: flex-start;"><section style="display: flex; margin-bottom: -7px; margin-left: 15px;"><section style="width: 0px; height: 1px; border-top: 6px solid transparent; border-bottom: 6px solid transparent; border-left: 10px solid #ffd97d; margin-right: 3px; margin-left: 3px; overflow: hidden;"></section><section style="width: 0px; height: 1px; border-top: 6px solid transparent; border-bottom: 6px solid transparent; border-left: 10px solid #ffd97d; margin-right: 3px; margin-left: 3px; overflow: hidden;"></section><section style="width: 0px; height: 1px; border-top: 6px solid transparent; border-bottom: 6px solid transparent; border-left: 10px solid #ffd97d; margin-right: 3px; margin-left: 3px; overflow: hidden;"></section></section></section><section style="padding: 15px 15px 10px; border: 1px solid #98cc6a;"><section style="line-height: 1.75em; letter-spacing: 1.5px; font-size: 14px; color: #333333;"><p style="text-indent: 2.1875em;"><span style="font-size: 16px; caret-color: #ff0000; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;">阿尔茨海默病是一种常见的神经系统退行性疾病，病症包括记忆障碍、失语、失认、视空间能力损害等，是老年期最常见的一种痴呆类型。该疾病发病原因尚未明确，但其病理特征明确，</span><span style="color: #c00000;"><strong><span style="font-size: 16px; caret-color: #ff0000; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;">即患者的大脑出现β淀粉样蛋白斑块的水平升高、Tau蛋白和神经纤维缠结形成，最终导致神经元及其突触丧失</span></strong></span><span style="font-size: 16px; caret-color: #ff0000; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;">。</span></p><p style="text-indent: 2.1875em;"> </p><p style="text-indent: 2.1875em;"><span style="font-size: 16px; caret-color: #ff0000; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;">在此之前，针对阿尔茨海默病患者的治疗方案都是以对症治疗为主。新药仑卡奈单抗的出现带来了新的治疗方案。“通俗地说，</span><span style="color: #c00000;"><strong><span style="font-size: 16px; caret-color: #ff0000; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;">就是仑卡奈单抗能够特异性识别并清除患者大脑中的β淀粉样蛋白，减少神经元的损伤和死亡，延缓疾病进展。</span></strong></span><span style="font-size: 16px; caret-color: #ff0000; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;">”<span style="color: #333333; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif; font-size: 16px; letter-spacing: 1.5px; text-indent: 30.625px; caret-color: #ff0000; text-wrap: wrap;">市中心医院党委委员、副院长，浙大一院神经内科副主任医师张侃</span>指出。</span></p><p style="text-indent: 2.1875em;"> </p><p style="text-indent: 2.1875em;"><span style="font-size: 16px; caret-color: #ff0000; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;">今年1月，仑卡奈单抗获我国国家药监局批准，用于治疗由阿尔茨海默病引起的轻度认知障碍和阿尔茨海默病轻度痴呆（在整个阿尔茨海默病患者群体中，这部分患者大约占总数的30%至50%），对于有效维持患者生活能力、改善生活质量具有重要意义。</span></p></section><section style="width: 100%; border-bottom: 1px dashed #98cc6a; margin-top: 10px; height: 1px; overflow: hidden;"></section></section></section></section><p> </p><section><section style="margin: 10px auto; display: flex; justify-content: center;"><section style="display: flex; flex-direction: column;"><section style="display: flex; justify-content: flex-start; z-index: 4;"><section style="display: flex; align-items: center; margin-bottom: -25px;"><section style="width: 40px;"></section><section style="width: 40px; text-align: center; margin-left: -40px; z-index: 4;"><section style="font-size: 16px; letter-spacing: 1.5px; color: #ffffff;"><strong>0</strong><strong title="">2</strong></section></section></section></section><section style="margin-left: 15px; display: flex; align-items: flex-end;"><section style="padding: 6px 10px 6px 35px; background-color: #98cc6a; transform: skew(-10deg);"><section style="transform: skew(10deg); -webkit-transform: skew(10deg); -moz-transform: skew(10deg); -o-transform: skew(10deg);"><section style="font-size: 16px; color: #ffffff; text-align: center;"><strong>尽早筛查、诊断和干预</strong></section></section></section><section style="flex-shrink: 0; margin-left: -6px;"><section style="width: 0px; height: 1px; border-left: 10px solid #81bc4c; border-top: 30px solid transparent; overflow: hidden;"></section></section></section></section></section></section><p> </p><section><section style="margin: 10px auto;"><section style="display: flex; justify-content: flex-start;"><section style="display: flex; margin-bottom: -7px; margin-left: 15px;"><section style="width: 0px; height: 1px; border-top: 6px solid transparent; border-bottom: 6px solid transparent; border-left: 10px solid #ffd97d; margin-right: 3px; margin-left: 3px; overflow: hidden;"></section><section style="width: 0px; height: 1px; border-top: 6px solid transparent; border-bottom: 6px solid transparent; border-left: 10px solid #ffd97d; margin-right: 3px; margin-left: 3px; overflow: hidden;"></section><section style="width: 0px; height: 1px; border-top: 6px solid transparent; border-bottom: 6px solid transparent; border-left: 10px solid #ffd97d; margin-right: 3px; margin-left: 3px; overflow: hidden;"></section></section></section><section style="padding: 15px 15px 10px; border: 1px solid #98cc6a;"><section style="line-height: 1.75em; letter-spacing: 1.5px; font-size: 14px; color: #333333;"><p style="text-align: left; max-inline-size: 100%; cursor: text; font-size: 17px; caret-color: #ff0000; text-indent: 2em; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;"><span style="max-inline-size: 100%; cursor: text; font-size: 16px;">“终于看到希望了！”小丁的母亲今年56岁，一年前出现神情疲惫、记忆力下降的表现，半年前在市中心医院被诊断为轻度阿尔茨海默病。这半年以来，小丁陪着母亲定期到医院检查、治疗，希望母亲不要那么快忘了她、忘了身边的人和事。新治疗方式的出现给了她希望。</span></p><p style="text-align: left; max-inline-size: 100%; cursor: text; font-size: 17px; caret-color: #ff0000; text-indent: 2em; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;"> </p><p style="text-align: left; max-inline-size: 100%; cursor: text; font-size: 17px; caret-color: #ff0000; text-indent: 2em; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;"><span style="max-inline-size: 100%; cursor: text; font-size: 16px;">张侃说：“每半个月注射一针仑卡奈单抗，可延缓疾病进展27%。但需要注意的是，</span><span style="color: #c00000;"><strong><span style="max-inline-size: 100%; cursor: text; font-size: 16px;">仑卡奈药物主要针对具有β淀粉样蛋白沉积的早期患者，因此建议使用该药物前需要完善患者的整体认知功能、核磁共振（评估脑微出血）、Aβ-PET、APOE基因型等相关检查</span></strong></span><span style="max-inline-size: 100%; cursor: text; font-size: 16px;">，确保符合药物适应症，以及要做好药物不良反应监测。”</span></p><p style="text-align: left; max-inline-size: 100%; cursor: text; font-size: 17px; caret-color: #ff0000; text-indent: 2em; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;"> </p><p style="text-align: left; max-inline-size: 100%; cursor: text; font-size: 17px; caret-color: #ff0000; text-indent: 2em; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;"><span style="max-inline-size: 100%; cursor: text; font-size: 16px;">同时，张侃还提醒，并非只有老年人才会得阿尔茨海默病，临床最年轻患者甚至不足四十岁。</span><span style="color: #c00000;"><strong><span style="max-inline-size: 100%; cursor: text; font-size: 16px;">轻度认知障碍阶段不给予足够的早期干预，会导致患者错过治疗的“黄金窗口期”</span></strong></span><span style="max-inline-size: 100%; cursor: text; font-size: 16px;">，因此建议</span><span style="color: #c00000;"><strong><span style="max-inline-size: 100%; cursor: text; font-size: 16px;">尽早筛查、诊断和干预</span></strong></span><span style="max-inline-size: 100%; cursor: text; font-size: 16px;">，为延缓和防控阿尔茨海默病赢得更多时间。</span></p><p> </p></section><section style="width: 100%; border-bottom: 1px dashed #98cc6a; margin-top: 10px; height: 1px; overflow: hidden;"></section></section></section></section><section><p> </p></section><section><section style="margin: 10px auto; display: flex; justify-content: center;"><section style="display: flex; flex-direction: column;"><section style="display: flex; justify-content: flex-start; z-index: 4;"><section style="display: flex; align-items: center; margin-bottom: -25px;"><section style="width: 40px;"></section><section style="width: 40px; text-align: center; margin-left: -40px; z-index: 4;"><section style="font-size: 16px; letter-spacing: 1.5px; color: #ffffff;"><strong>0</strong><strong title="">3</strong></section></section></section></section><section style="margin-left: 15px; display: flex; align-items: flex-end;"><section style="padding: 6px 10px 6px 35px; background-color: #98cc6a; transform: skew(-10deg);"><section style="transform: skew(10deg); -webkit-transform: skew(10deg); -moz-transform: skew(10deg); -o-transform: skew(10deg);"><section style="font-size: 16px; color: #ffffff; text-align: center;"><strong>如何判断阿尔茨海默病</strong></section></section></section><section style="flex-shrink: 0; margin-left: -6px;"><section style="width: 0px; height: 1px; border-left: 10px solid #81bc4c; border-top: 30px solid transparent; overflow: hidden;"></section></section></section></section></section></section><p> </p><section><section style="margin: 10px auto;"><section style="display: flex; justify-content: flex-start;"><section style="display: flex; margin-bottom: -7px; margin-left: 15px;"><section style="width: 0px; height: 1px; border-top: 6px solid transparent; border-bottom: 6px solid transparent; border-left: 10px solid #ffd97d; margin-right: 3px; margin-left: 3px; overflow: hidden;"></section><section style="width: 0px; height: 1px; border-top: 6px solid transparent; border-bottom: 6px solid transparent; border-left: 10px solid #ffd97d; margin-right: 3px; margin-left: 3px; overflow: hidden;"></section><section style="width: 0px; height: 1px; border-top: 6px solid transparent; border-bottom: 6px solid transparent; border-left: 10px solid #ffd97d; margin-right: 3px; margin-left: 3px; overflow: hidden;"></section></section></section><section style="padding: 15px 15px 10px; border: 1px solid #98cc6a;"><section style="line-height: 1.75em; letter-spacing: 1.5px; font-size: 14px; color: #333333;"><p style="text-align: left; max-inline-size: 100%; cursor: text; font-size: 17px; caret-color: #ff0000; text-indent: 2.1875em; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;"><span style="max-inline-size: 100%; cursor: text; font-size: 16px;">早期表现：睡眠障碍，如入睡困难、易醒多梦、白天倦困、神情疲惫等。常伴记忆障碍，包括记忆减退、忘却。</span></p><p style="text-align: left; max-inline-size: 100%; cursor: text; font-size: 17px; caret-color: #ff0000; text-indent: 2.1875em; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;"> </p><p style="text-align: left; max-inline-size: 100%; cursor: text; font-size: 17px; caret-color: #ff0000; text-indent: 2.1875em; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;"><span style="max-inline-size: 100%; cursor: text; font-size: 16px;">中期表现：记忆力下降是核心症状，发展缓慢而不明显，在5至10年内逐渐加重，终致远近记忆都受损，并出现情绪、性格和行为的改变，生活节律紊乱。</span></p><p style="text-align: left; max-inline-size: 100%; cursor: text; font-size: 17px; caret-color: #ff0000; text-indent: 2.1875em; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;"> </p><p style="text-align: left; max-inline-size: 100%; cursor: text; font-size: 17px; caret-color: #ff0000; text-indent: 2.1875em; font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;"><span style="max-inline-size: 100%; cursor: text; font-size: 16px;">晚期表现：智能严重损害，反应淡漠或出现幻觉，生活需要照顾，生理功能锐减，易发生并发症。该阶段在检查时可发现逐渐增加的脑神经损害体征。</span></p></section></section></section></section></section></section></section></section></section><section style="margin-bottom: 0px; letter-spacing: 0.578px; text-wrap: wrap; background-color: #ffffff; outline: 0px; font-size: 16px; caret-color: rgba(0, 0, 0, 0); text-align: center; visibility: visible; font-family: system-ui, -apple-system, BlinkMacSystemFont, Arial, sans-serif;"><section style="outline: 0px; visibility: visible;"><section style="outline: 0px;"><section style="outline: 0px; text-align: left;"></section><section style="outline: 0px; text-align: left;"><span style="outline: 0px; letter-spacing: 0.54px; color: #888888; font-size: 12px; text-align: center; visibility: visible; font-family: -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;">来源 |</span><span style="outline: 0px; color: #888888; font-size: 12px; letter-spacing: 0.54px; text-align: center; font-family: -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;"> </span><span style="outline: 0px; color: #888888; font-size: 12px; letter-spacing: 0.54px; text-align: center; font-family: -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;">义乌市融媒体中心</span></section></section></section></section><p style="display: none;"> </p> <!----></div>
神州大呼一鸥
发表于 2024-7-9 09:07:25
老年痴呆症患者的福音
不能～说的秘密
发表于 2024-7-9 09:10:27
真好啊
那年星辰
发表于 2024-7-9 09:10:46
呵呵
文明和谐共存
发表于 2024-7-9 09:14:10
好的
zgj
发表于 2024-7-9 09:19:43
部分病人有点希望了
dogpile
发表于 2024-7-9 09:24:14
电饭锅好几块皇冠夫妇发
法海你懂爱吗
发表于 2024-7-9 09:27:15
说个价格让我死心
咖啡也有甜的
发表于 2024-7-9 09:32:18
我也好担心会老年痴呆:Q
nshshui1
发表于 2024-7-9 09:37:25
用钱换命
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